Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
This is a highly specific antibody against HPV16-E7. This antibody may also detect HPV35-E7
KLH conjugated synthetic peptide derived from middle of HPV16-E7
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
This antibody was purified via Protein A.
HPV16-E7 Primary Polyclonal Antibody
WB, IHC-P, IF(IHC-P)
Protein E7; E7
1ug per 1ul