6

HPV33 E6 Antibody, Cy5.5 Conjugated

Details

HPV33 E6 Antibody, Cy5.5 Conjugated

Name

bs-2968R-Cy5.5

Catalog Number

350 EUR

Price

0.1ml

Size

More information

Antigen background

Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. The E6 protein is a transcriptional transactivator. Binds double-stranded DNA. This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).

Properties

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.

Synonyms

E6 protein [Human papillomavirus type 33]; Human Papilloma Virus; Human papillomavirus type 33; Human papillomavirus type 33; Protein 33; HPV33-E6 protein; HPV33 E6 protein; VE6_HPV33.

Storage conditions

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

Specificity

This is a highly specific antibody against HPV33 E6. This antibody will detect E6 in HPV33, HPV58, and Alphapapillomavirus 9.

Conjugated

These antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.

Source

KLH conjugated synthetic peptide derived from human HPV33 E6 protein

Long name

HPV33 E6 Polyclonal Antibody, Cy5.5 Conjugated

Purification method

This antibody was purified via Protein A.

Crossreactive species details

HPV33, HPV58, Alphapapillomavirus 9.

Host Organism

Rabbit (Oryctolagus cuniculus)

Category

Conjugated Primary Antibodies

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Concentration

1ug per 1ul

Additional conjugation

Cy5.5,Cy5.5

Excitation Emission

675nm/694nm

Modification

Unmodified

Clonality

Polyclonal

Immunogen_range

90-140/149

Tested applications

IF(IHC-P)

French translation

anticorps

Target Antigen

HPV33 E6

Subcellular location

Nucleus

Crossreactivity

Virus

Conjugation

Cy5.5

Modification site

None

Back to top