E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
This is a highly specific antibody against HPV33 E7. This antibody will also detect E7 in HPV58, but with slightly less affinity, due to a one amino acid change in the immunogen sequence range.
E7 protein [Human papillomavirus type 33]; Human Papilloma Virus; Human papillomavirus type 33; Human papillomavirus type 33; Protein 33; early protein E7 [Human papillomavirus type 33].
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
KLH conjugated synthetic peptide derived from HPV33 E7
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
This antibody was purified via Protein A.
HPV33 E7 Primary Polyclonal Antibody
WB, IHC-P, IF(IHC-P)
Polyclonal antibody
Unmodified antibody
Polyclonal antibody
Primary Antibodies
HPV33 E7 PAb
Unconjugated
1ug per 1ul
anticorps
30-80/97
HPV33 E7
Nucleus
HPV33
Virus
None