Transcriptional transactivator. Binds double-stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.
Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
synthetic peptide from HPV16 E6 + HPV18 E6 conjugated to KLH
This antibody reacts specifically with HPV16 E6 + HPV18 E6
No modification has been applied to this antibody
For facs or microscopy Alexa 1 conjugate.
HPV16 E6 + HPV18 E6 Polyclonal Antibody
Anti-HPV16 E6 + HPV18 E6 Polyclonal
Rabbit (Oryctolagus cuniculus)
Alexa Fluor,ALEXA FLUOR® 594
Conjugated Primary Antibody
Polyclonals and antibodies
Purified by Protein A.
HPV16 E6 + HPV18 E6
ALEXA FLUOR® 594
Alexa conjugate 1
Protein E6; E6
1ug per 1ul